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KMID : 1123920080220040993
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 4 p.993 ~ p.999
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Study on The Responseness to Oriental Medicine Therapy and Single-Nucleotide Polymorphism in Korean Cerebral Infarction Patients
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Lee Se-Yun
Lee Yoon-Kyoung
Kim Jae-Soo
Lee Kyung-Min
Jung Tae-Young
Lim Seong-Chul
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Abstract
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Ischemic brain injury such as cerebral infarction is characterized by acute local inflammatory response mediated by cytokines. The mechanism of cytokines involved in cerebral infarction progression are uncompletely revealed yet. We investigated to find out the relationship between single nucleotide polymorphism (SNP) of interleukin 4 receptor(IL4R) and Oriental Medicine therapy efficacy in patients with cerebral infarction for 2 weeks. Oriental Korean Medicine therapies (herbal medicine and acupuncture) were applied daily and motor functions of patients were assessed using the modified cerebral vascular accident (MCVA) scores. Genotyping for IL4R polymorphism was done by pyrosequencing analysis. In IL4R genotypes and the frequency of alleles, there was no significant difference between cerebral infarction patients (n=124) and controls group (n=175). And there was also no significant difference among good and bad responders in cerebral infarction patients. In this study the IL4R genotype might not be the risk factor or a good predictive genetic marker for good and bad responders in cerebral infarction patients in Korean. Further studies including different cytokine genes will be necessary for the exact genetic markers.
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KEYWORD
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Interleukin 4 Receptor (IL4R), gene, polymorphism, cerebral infarction, modified cerebral vascular accident (MCVA) scores, Oriental Medicine therapy
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